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Cyclosporine is apotent immuno suppressive agent that has been shown to work via suppression of T-helper and T-suppressor cells and inhibition of interleukin-2. It does notim pair the hematopoietic system or cell-mediated immunologic responses. Adecrease in CD4 and CD8 cells was not seen in dogs receiving 20 mg/kg/day of cyclosporine for 56 days. Cyclosporine is not a corticosteroid or an antihistamine.
Cyclosporine isextensively metabolized by the cytochrome P-450 enzyme system in the liver, andto a lesser degree in the gastrointestinal tract and the kidney.
Cyclosporine is indicated for the treatment of at opic dermatitis in dogs.
Cyclosporine can also be used as an aid in the treatment of perianal fistulaein dogs. A perianal fistula is a syndrome of inflammation, ulceration and draining sinuses in the perianal (around the anus) region of dogs, particularly German Shepherds. It is thought to be an immune-mediated condition.
Perianal fistula is extremely painful, malodorous and often requires surgery.Limited studies have been done on the use of cyclosporine for the treatment of perianal fistulae in dogs. However, cyclosporine may help reduce or resolve symptoms.
Cyclosporine is apotent systemic immuno suppressant that may increase the susceptibility to infection and the development of neoplasia.
Not for human use. Keep this and all drugs out of reach of children. For use only in dogs.
PREGNANCY AND LACTATION:
The safety of cyclosporine has not been studied in breeding male dogs nor in pregnant or lactating female dogs.
Cyclosporine passes the placenta barrier and is excreted via milk, therefore the treatment of lactating bitches is not recommended. Your veterinarian should be advised if your dog is a breeding animal, so that a risk/benefit assessment can be made.