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Each soft gelatincapsule contains:
CyclosporineUSP 50 mg
CATEGORY: PotentImmunosuppressive Agent
Cyclosporine is apotent immunosuppressive agent that has been shown to work via suppression ofT-helper and T-suppressor cells and inhibition of interleukin-2. It does notimpair the hematopoietic system or cell-mediated immunologic responses. Adecrease in CD4 and CD8 cells was not seen in dogs receiving 20 mg/kg/day ofcyclosporine for 56 days. Cyclosporine is not a corticosteroid or anantihistamine.
Cyclosporine isextensively metabolized by the cytochrome P-450 enzyme system in the liver, andto a lesser degree in the gastrointestinal tract and the kidney.
â¢ Cyclosporine is indicated for the treatment of atopic dermatitis in dogs.
â¢ Cyclosporine can also be used as an aid in the treatment of perianal fistulaein dogs. A perianal fistula is a syndrome of inflammation, ulceration anddraining sinuses in the perianal (around the anus) region of dogs, particularlyGerman Shepherds. It is thought to be an immune-mediated condition.
â¢ Perianal fistula is extremely painful, malodorous and often requires surgery.Limited studies have been done on the use of cyclosporine for the treatment ofperianal fistulae in dogs. However, cyclosporine may help reduce or resolvesymptoms.
Cyclosporine is apotent systemic immunosuppressant that may increase the susceptibility toinfection and the development of neoplasia.
Not for human use. Keepthis and all drugs out of reach of children. For use only in dogs.
The safety ofcyclosporine has not been studied in breeding male dogs nor in pregnant orlactating female dogs.
Cyclosporine passes theplacenta barrier and is excreted via milk, therefore the treatment of lactatingbitches is not recommended. Your veterinarian should be advised if your dog isa breeding animal, so that a risk/benefit assessment can be made.